The honey badger is the only species of the genus Mellivora. Although in the 1860s it was assigned to the badger subfamily, the Melinae it is now generally agreed that it bears very few similarities to the Melinae. It is much more closely related to the Marten subfamily, Mustelinae, but furthermore is assigned its own subfamily, Mellivorinae. Differences between Mellivorinae and Melinae include differences in their dentition formulae. Though not in the same subfamily as the wolverines, which are a genus of large-sized and atypical Mustelinae, the honey badger can be regarded as another, analogous, form of outsized weasel or polecat.

The species first appeared during the middle Pliocene in Asia. Its closest relation was the extinct genus Eomellivora, which is known from the upper Miocene, and evolved into several different species throughout the whole Pliocene in both the Old and New World.